Publications:
 

*- W&M undergraduate                          § - W&M Masters

                                                                            student     





¤ -W&M Technician                                     ¶ - W&M colleague                         





                *- Area High School Student




¤- indicates shared first authorship and equal contributions.

Regulation of Outer Membrane Protein Expression in Helicobacter pylori. R-15 AI133470. National Institute of Allergy & Infectious Diseases (NIAID). 12/01/2018 - 11/30/2021. $412,542. Evolution of a bacterial genome encoding increased virulence: the genomics of Helicobacter pylori isolates lacking the cag pathogenicity island. R15, National Institutes of Health (NIAID). $ 345,999.00. AI053062-04. (NIAID) 7/01/2012 to 6/30/2015. Signal Transduction Pathways and Networks in the Gastric Pathogen, Helicobacter pylori. 7/28/09-6/30/12.  The National Institutes of Health / National Institute of Allergy and Infectious Diseases (NIAID).   R15   2-AI053062-03.  $ 208,613. Signal Transduction Response in Helicobacter pylori-Renewal.  5/1/06-4/30/09.  The National Institutes of Health / National Institute of Allergy and Infectious Diseases (NIAID).   R15   2-AI053062-02.  $ 211,060. Signal Transduction Response in Helicobacter pylori.  5/15/03 to 4/30/06.  The National Institutes of Health / National Institute of Allergy and Infectious Diseases (NIAID).   R15 1-AI053062-01.  $ 133,750. Comparative Genomics of the Gastric Pathogenic Bacterium Helicobacter pylori; The Genetics of Avirulence.  7/04 to 6/05.  The Commonwealth Health Research Board.    $ 35,000. A Comparative Genomic Approach to Genetic Diversity Among Virulent and Avirulent Helicobacter pylori Isolates.  1/1/2001 to 12/31/2003.  The Thomas and Kate Miller Jeffress Memorial Trust.  J-602.  $ 41,675.
Grant Support:
Geary, S.J., and M.H. Forsyth.   1996.   PCR: random amplified polymorphic DNA fingerprinting. in  Molecular and Diagnostic Procedures in Mycoplasmology  Vol. 2,  Chapter A8.  81-85.  J.G. Tully and S. Razin eds.  Academic Press, New York.
Book Chapters:
Daniel R. Hallinger §, J. Romero-Gallo, Richard M. Peek Jr., & M.H. Forsyth. 2012. Polymorphisms of the acid sensing histidine kinase gene arsS in Helicobacter pylori populations from anatomically distinct gastric sites. Microbial Pathogenesis. 53:227-233. pdf 26. Pope WH, Ferreira CM, Jacobs-Sera D, Benjamin RC, Davis AJ, Dejong RJ, Elgin SC, Guilfoile FR, Forsyth MH, Harris AD, Harvey SE, Hughes LE, Hynes PM, Jackson AS, Jalal MD, MacMurray EA, Manley CM, McDonough MJ, Mosier JL, Osterbann LJ, Rabinowitz HS, Rhyan CN, Russell DA, Saha MS, Shaffer CD, Simon SE, Sims EF, Tovar IG, Weisser EG, Wertz JT, Weston-Hafer KA, Williamson KE, Zhang B, Cresawn SG, Jain P, Piuri M, Jacobs WR Jr, Hendrix RW, Hatfull GF. 2011. Cluster K Mycobacteriophages: Insights into the Evolutionary Origins of Mycobacteriophage TM4. PLoS One. 2011;6(10):e26750. Epub 2011 Oct 28. 25. Pope, W.H., authors51, M.H. Forsyth, authors8, K.C. Gordon, authors9, S.E. Harvey, authors11, A.S. Jackson, authors26, M.J. McDonough, authors11, A.M. Perz, authors15, M.S. Saha, authors31, J.M. Walton, authors6, H.M. Whelan, K.E. Williamson, authors10, and G.F. Hatfull. 2011. Expanding the diversity of mycobacteriophages: insights into genome architecture and evolution. PLoS One. 2011 Jan 27;6(1):e16329. 24. Gunderson, A.R.§, M.H. Forsyth, and J.P. Swaddle¶. 2009.  Evidence that plumage bacteria influence feather coloration and body condition of a passerine. Journal of Avian Biology 40:440-447. pdf Andrew C. Goodwin*¤, Daniel M. Weinberger*¤, Christopher B. Ford§, Jessica C. Nelson*, Jonathan Snider*, Joshua D. Hall*, Catharine I. Paules*, Richard M. Peek Jr., and M. H. Forsyth.  2008.  Expression of the Helicobacter pylori Adhesin SabA is Controlled via Phase Variation and the ArsRS Signal Transduction System. Microbiology.  154:2231-2240.  pdf Alexander Gunderson§, Alicia Frame*, John P. Swaddle¶, and M.H. Forsyth.  2008.  Resistance of melanized feathers to bacterial degradation; is it really so Black and White?  J. Avian Biol. 39:539-545. pdf     
 Courtney E. Terry*, Lisa M. McGinnis*, Katharine C. Madigan*, P. Cao, T. L. Cover, George W. Liechti§, R.M. Peek  Jr., and M. H. Forsyth.  2005.  Genomic Comparison of cag Pathogenicity Island (PAI)-Positive and -Negative Helicobacter pylori Strains: Identification of Novel Markers for cag PAI- Positive Strains.  Infect. Immun. 73:3794-3798.    pdf Justine M. Whitaker§, Daniel. A. Cristol¶, and M.H. Forsyth. 2005.  Prevalence and Genetic Diversity of Bacillus licheniformis in Avian plumage.  J. Field Ornithol.  76(3):265-271.  pdf

19.  Daniel. A. Cristol¶, Jessica. L. Armstrong*, Justine. M. Whitaker§, and M. H. Forsyth.  2005.  Feather-Degrading Bacteria Do Not Affect Feathers on Captive Birds.    Auk. 122:222-230. pdf  Shannon L. McNulty*¤, Beth M. Mole*¤, D. Dailidiene, I. Segal, R. Ally, R. Mistry, O. Secka, R. A. Adegbola, J. E. Thomas, Erik M. Lenarcic*, R. M. Peek, Jr., D. E. Berg, M. H. Forsyth.  2004.   Novel 180-  and 480-Base Pair Insertions in African and African-American Strains of Helicobacter pylori.    J. Clin. Microbiol. 42(12):5658-5663.  pdf Loh J.T., Forsyth M.H., and T. L. Cover.  2004.  Growth Phase Regulation of flaA Expression in Helicobacter pylori is luxS Dependent.  Infect. Immun. 72:5506-5510.   pdf McGowan C.C., Necheva A.S., Forsyth M.H., Cover T.L., and Blaser M. J.  2003.   Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH.   Mol. Microbiol. 48(5):1225-1239.    Forsyth M. H., Cao P., Preston. P. Garcia¤. Joshua. D. Hall *, and T. L. Cover.  2002.  Genome-wide transcriptional profiling in a histidine kinase mutant of Helicobacter pylori identifies members of a regulon. J. Bacteriol. 184:4630-4635.   pdf Forsyth M.H., and T. L. Cover.  2000.  Intercellular communication in Helicobacter pylori : luxS  is essential for the production of an extracellular signaling molecule. Infect. Immun.  68:3193-3199.    pdf Forsyth M. H., and T. L. Cover.  1999.  Mutational analysis of the vacA promoter provides insight into gene transcription in Helicobacter pylori.    J. Bacteriol. 181:2261-2266. pdf Peek, Jr., R. M., M. J. Blaser, D. J. Mays, M.H. Forsyth, T. L. Cover, S. Y. Song, U. Krishna, and J. A. Pietenpol.  1999. Helicobacter pylori  strain-specific genotypes in modulation of the gastric epithelial cell cycle. Cancer Res.  59:6124-6131.  Goh, M. S., T. S. Gorton, M.H. Forsyth, K. E. Troy, and S. J. Geary.   1998. Molecular and biochemical analysis of a 105 kDa Mycoplasma gallisepticum cytadhesin (GapA).  Microbiology  144:2971-2978. Forsyth M. H., J.C. Atherton, M.J. Blaser, and T. L. Cover.  1998.  Heterogeneity in levels of vacuolating cytotoxin gene (vacA ) transcription among Helicobacter pylori  strains.  Infect. Immun.  66:3088-3094. pdf Cao, P., M. S. McClain, M.H. Forsyth, and T. L. Cover  1998.  Extracellular release of antigenic proteins by Helicobacter pylori. Infect. Immun.  66:2984-2986 Karita, M., M. Etterbeek, M.H. Forsyth, M. K. R. Tummuru, and M.J. Blaser.  1997.  Characterization of the Helicobacter pylori dapE gene; a conditionally lethal dapE - mutant and the implications for treatment and a vaccine.  Infect. Immun. 65:4158-4164. Frasca, S., L. Hinckly, M.H. Forsyth, T. S. Gorton, S. J. Geary, and H.J. Van Kruiningen.  1997.   Conjunctivitis and episcleritis in a European Starling (Sturnus vulgaris) associated with a novel mycoplasma, Mycoplasma sturni.J. of Wildlife Diseases 33:336-339. Forsyth, M.H., J. G. Tully, S. Frasca, L. Hinckley, T. S. Gorton, H. J. Van Kruiningen, and S.J. Geary.     Mycoplasma sturni sp. nov., from the conjuntiva of a European Starling (Sturnus vulgaris). Int. J. Systematic Bact.  46:716-719. Forsyth, M.H., and S.J. Geary.   1996.  The repetitive element, Rep MP 1, of Mycoplasma pneumoniae  exists as a core element within a larger repetitive mosaic. J. Bact.  178: 917-921.  Forsyth, M.H., S. Saoud, and S.J. Geary.   1995.   Cloning and transcriptional analysis of the genes for the class II topoisomerase, DNA gyrase, of  Mycoplasma gallisepticum.   Gene 163:161-162. Geary, S.J., M.H. Forsyth, S. Saoud, D. E. Berg, G. Wang, and C.M. Berg.  1994. Random amplified polymorphic DNA fingerprinting of Mycoplasma gallisepticum.   Mol. and Cell. Probes  8:311-316. Geary, S.J., J. A. Ryan, M.H. Forsyth, and G.V. Sasseville.   1993.  Development of monoclonal antibodies for the detection of mycoplasma infection and contamination.    Mol.and Cell. Probes  7:133-138. Forsyth, M.H., M. E. Tourtellotte, and S.J. Geary.   1992.   Localization of an immunodominant 64 kDa lipoprotein (LP 64) in the membrane of Mycoplasma gallisepticum and its role in cytadherence. Mol. Microbiol.  6:2099-2106. Publications_and_Support_files/Hallinger%20et%20al.%20Microbial%20Path%202012.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/22053209http://www.ncbi.nlm.nih.gov/pubmed/22053209Publications_and_Support_files/Gunderson09-BluebirdFDB%3BJAB.PDFPublications_and_Support_files/2231.pdfPublications_and_Support_files/Gunderson%20et%20al.2008.pdfPublications_and_Support_files/Terry%20et%20al.2005.pdfhttp://mhfors.people.wm.edu/Terry%20et%20al.2005.pdfPublications_and_Support_files/Whitaker%20et%20al.pdfPublications_and_Support_files/Auk%202005.pdfPublications_and_Support_files/McNulty%20et%20al.%202004.pdfPublications_and_Support_files/LohForsythCover2004.pdfPublications_and_Support_files/4630.pdfPublications_and_Support_files/3193.pdfPublications_and_Support_files/2261.pdfPublications_and_Support_files/3088.pdfshapeimage_6_link_0shapeimage_6_link_1shapeimage_6_link_2shapeimage_6_link_3shapeimage_6_link_4shapeimage_6_link_5shapeimage_6_link_6shapeimage_6_link_7shapeimage_6_link_8shapeimage_6_link_9shapeimage_6_link_10shapeimage_6_link_11shapeimage_6_link_12shapeimage_6_link_13shapeimage_6_link_14shapeimage_6_link_15

  1. 28. Vivian Cooper Harvey*¤, Catherine R. Acio*¤, Amy K. Bredehoft*, Laurence Zhu*, Daniel R.     

        Hallinger §, Vanessa Quinlivan-Repasi §, Samuel E. Harvey*, and M. H. Forsyth.  2014.

        Repetetitive Sequence Variations in the Promoter Region of the Adhesin Encoding Gene sabA of

        Helicobacter pylori Affect Transcription.  J. Bacteriol.  196(19):3421-9.  url

29. Carpenter, B.M., West, A.L., Gancz, H., Servetas, S.L., Pich, O. Q., Gilbreath, J. J.,  Hallinger,    

        D.R.§, Forsyth, M. H., Merrell, D.S., & S. L. H. Michel.  2015.  Crosstalk between the HpArsRS

        two-component system and HpNikR is necessary for maximal activation of urease transcription.

       Fronteirs in Microbiol. 6:558;1-18.  url


      

  1. 31.  Catherine R. Acio-Pizzarello*, Abigail A. Acio*, Edward J. Choi*, Kimberly Bond*, June Kim*, Anna C.  

        Kenan*, Jiajia Chen*, and M. H. Forsyth.  2017.  Determinants of the Regulation of Helicobacter pylori

        Adhesins Include Repeat  Sequences in both Promoter and Coding Regions as well as the Two Component System

        ArsRS.  J. Med. Microbiol.  66:798-807.

30.  Krishna U, Romero-Gallo J, Suarez G, Azah A, Krezel AM, Varga MG, Forsyth MH, Peek RM Jr.

        Genetic Evolution of a Helicobacter pylori Acid-Sensing Histidine Kinase and Gastric Disease.  2016.

        J. Infect. Dis. 214:644-648

33.  Danielle N. Horridge*, Allison A. Begley*, June Kim*, Neeraja Aravindan*, Kexin Fan*, 

       and M. H. Forsyth. 2017.  Outer Inflammatory Protein A (OipA) of Helicobacter pylori is  

       Regulated by Host Cell Contact and Mediates CagA Translocation and Interleukin 8 Response  

       only in the Presence of a Functional cag PAI Type IV Secretion System.  Pathogens & Disease.  Nov. 30; 75(8). doi: 10.1093/femspd/ftx113.  PMID: 29040466

  1. 32. Bullock KK,  Shaffer CL,  Brooks AW,  Secka O. Forsyth MH,  McClain MS, & TL Cover. 2017.  Genetic signatures for Helicobacter pylori strains of West African origin.  PLoS One.  Nov. 29; 12(11):e0188804.  doi:10.1371/journal.pone.0188804.eCollection 2017.  PMID:29186206